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Medicinal plants have always been considered a healthy source of life for all people. Mongolia is rich in medicinal and food plants. In recent years, interest in plant-derived food additives has grown. This study was designed to determine essential oil chemical composition and evaluate antioxidant, cytotoxic activities of aerial parts serial fractions from Caryopteris mongolica Bunge. grown in Mongolia. The chemical composition of leaf and flower essential oil from C. mongolica was determined by GC-MS analysis. A total of 66 compounds were identified in the leaf and flower accounting for 98.2% of the total composition. The most abundant components were α-thujene (18.7%), (E)-β-ocimene (11.0%), limonene (8.8%), β-pinene (8.0%), terpinen-4-ol (7.2%), α-pinene (6.3%), sabinene (5.6%), p-cymene (3.1%), selvestrene (2.4%), γ-terpinene (2.3%), germacrene (3.2%), δ-cadinene (2.1%), caryophyllene (1.8%), spathulenol (1.8%), α-terpinene (1.6%), cis-sabinen-hydrate acetate (1.4%), α-copaen (1.0%), (Z)-menth-2-en-1-ol (1.0), cis-sabinen hydrate (1.0%) and trans-carveol (0.7%). The ethanol crude extract of C. mongolica Bunge. was suspended in water and consequently fractionated with n-hexane, chloroform, ethyl acetate and butyl alcohol. All the fractions were examined for their antioxidant and cytotoxic activities by using DPPH and MTT assays, respectively. Ethyl acetate fraction shMedicinal plants have always been considered a healthy source of life for all people. Mongolia is rich in medicinal and food plants. In recent years, interest in plant-derived food additives has grown. This study was designed to determine essential oil chemical composition and evaluate antioxidant, cytotoxic activities of aerial parts serial fractions from Caryopteris mongolica Bunge. grown in Mongolia. The chemical composition of leaf and flower essential oil from C. mongolica was determined by GC-MS analysis. A total of 66 compounds were identified in the leaf and flower accounting for 98.2% of the total composition. The most abundant components were α-thujene (18.7%), (E)-β-ocimene (11.0%), limonene (8.8%), β-pinene (8.0%), terpinen-4-ol (7.2%), α-pinene (6.3%), sabinene (5.6%), p-cymene (3.1%), selvestrene (2.4%), γ-terpinene (2.3%), germacrene (3.2%), δ-cadinene (2.1%), caryophyllene (1.8%), spathulenol (1.8%), α-terpinene (1.6%), cis-sabinen-hydrate acetate (1.4%), α-copaen (1.0%), (Z)-menth-2-en-1-ol (1.0), cis-sabinen hydrate (1.0%) and trans-carveol (0.7%). The ethanol crude extract of C. mongolica Bunge. was suspended in water and consequently fractionated with n-hexane, chloroform, ethyl acetate and butyl alcohol. All the fractions were examined for their antioxidant and cytotoxic activities by using DPPH and MTT assays, respectively. Ethyl acetate fraction showed the highest DPPH radical scavenging activity at a concentration of 50 µg/ml by 91.19% with the IC50 value of 12.62 µg/ml. MTT results showed that essential oil and chloroform fraction demonstrated significant cytotoxicity against A549 – human alveolar basal epithelial cell line, with values of 94.96 and 93.24%; 83.64 and 59.81% (50; 10 µg/ml; at 48 h), and ethanol fraction established high cytotoxic activity against A431 – human epidermoid carcinoma cell line, with values of 89.64 and 33.41% (50; 10 µg/ml; at 48 h), then water fraction demonstrated higher activity against HepG2 – human liver cancer cell line, with values of 93.08 and 85.37% (40; 20 µg/ml; at 24 h). These suggest that the fractions of C. mongolica Bunge. could hold a good potential for use in the pharmaceutical industry. owed the highest DPPH radical scavenging activity at a concentration of 50 µg/ml by 91.19% with the IC50 value of 12.62 µg/ml. MTT results showed that essential oil and chloroform fraction demonstrated significant cytotoxicity against A549 – human alveolar basal epithelial cell line, with values of 94.96 and 93.24%; 83.64 and 59.81% (50; 10 µg/ml; at 48 h), and ethanol fraction established high cytotoxic activity against A431 – human epidermoid carcinoma cell line, with values of 89.64 and 33.41% (50; 10 µg/ml; at 48 h), then water fraction demonstrated higher activity against HepG2 – human liver cancer cell line, with values of 93.08 and 85.37% (40; 20 µg/ml; at 24 h). These suggest that the fractions of C. mongolica Bunge. could hold a good potential for use in the pharmaceutical industry.
This study aims to investigate the biochemical and functional properties of innovative curd-based products prepared by the traditional method. In this study, four samples (raw curd, curd powder, curd balls, and curd drink) were analyzed using Kjeldahl method for protein, Soxhlet for fat, atomic absorption spectrophotometry for minerals, RP-HPLC for amino acids and organic acids, SDS-PAGE and HPLC for protein fractions, DPPH assay for antioxidant activity, antibacterial assays, and laser diffraction for particle size distribution. The raw curd contained 13.96 ± 0.15 g protein, 6.77 ± 0.19 g fat, and 0.42 ± 0.05 g calcium, corresponding to 30.08 mg Ca per gram of protein. Lactic acid was the major organic acid, with concentrations ranging from 16.04 to 32.00 mg/g in curd balls and powder, respectively. The highest antioxidant activity was observed in raw material (72.3 ± 1.50% DPPH inhibition) followed by curd balls (53 ± 2.00%). Particle size analysis revealed a monomodal distribution with a median diameter (D50) of 3.7 ± 0.20 µm. Antibacterial activity was observed in non-neutralized samples, indicating pH-dependent inhibitory effects. These findings support the potential of traditionally fermented curd as a functional dairy product that preserves bioactive peptides and antioxidant properties while adapting to modern consumer demands.
Antibacterial and antiviral activities. In this study, we determined the antioxidant and antibacterial activities of Cacalia hastataL. extracts.Methods: The aerial parts of Cacalia hastataL. had been studied. These parts were extracted with 40%, 70%, 95% ethanol (1:10) by the remaceration method. Thin layer chromatography (TLC) was used for the identification of constituents as phenolic compounds and flavonoids, their quantities were determined by spectrophotometric methods, precipitation reactions were used for the qualitative analysis of the tannin, while its quantitative determination was performed by the direct titration with potassium permanganate using indigo sulfonic acid as an indicator. The antioxidant activity of extracts was evaluated by the DPPH assay and the antibacterial activity by the Agar diffusion method, respectively. Safflower (Carthamus tinctorius) has long been used to treat cardiovascular diseases. In this study, an injectable formulation of Carthamus tinctorius (CTI) was developed. Beyond its pharmacological benefits, potential toxicity must be thoroughly assessed. Previous studies have reported possible maternal, fetal, and teratogenic toxicities in rodents, while also suggesting fertility-enhancing properties, underscoring the need for further investigation. Aim: This study aimed to evaluate the potential toxicity effects of CTI in pregnant Wistar (Han) rats and their developing fetuses. The research followed OECD Guideline No. 414, the international standard for prenatal developmental toxicity testing. Methods: Pregnant rats were randomly divided into four groups (n=3 females/group): a control and three treatment groups receiving CTI at doses of 0.45 (low), 0.82 (medium), and 1.65 ml/kg (high). CTI was administered daily via intramuscular injection from gestational day (GD) 6 to 20. On GD21, cesarean sections were performed. Maternal parameters (body weight gain, ovaries with HE staining, corpora lutea count, and uterine examination) and fetal parameters (body weight, head cranium, tail length, placental weight) were evaluated. Results: Corrected maternal weight gain and fetal body weight were significantly reduced in low- and Results: Quantities of phenolic compounds in 40%, 70% and 95% extracts were determined as 4.87%, 4.92%, and 4.17%, respectively. Whereas, total flavonoids were as 4.61%, 5.1%, and 4.13%, respectively. The reaction with ferric ammonium slag presented dark green color, which indicated the presence of a condensable agent. Total tannins were 7.4% in the 40% extract, 5.1% in the 70% extract, and 3.04% in the 95% extract, respectively, by titration with the potassium permanganate. In addition, all 40%, 70% and 95% extracts showed moderate DPPH scavenging activity as IC50 =48.5μg/ mL, IC50 =74.8μg/mL, IC50 =51.2 μg/mL, respectively, comparad to rutin. The 40% and 70% extracts exhibited antibacterial activity against Bacillus subtillis with 3mm and 4mm inhibition zones, respectively. Conclusion: According to the results, the 70% ethanol extract of Cacalia hastata L. was more rich in biologically active products such as phenolic compounds, and flavonoids, and its extracts demonstrated antioxidant and antibacterial activities. Author(s), 2025 high-dose groups compared to the control. Increased anogenital distance index and congenital abnormalities, *Corresponding author: Department of General Science, Mongolian University of Pharmaceutical Sciences, Sonsgolon’s road 4/A, Songinokhairkhan District, 20th khoroo, Ulaanbaatar, Mongolia; E-mail address: badral @monos.mn; Tel.99099947 such as hydrocephalus, were observed in some fetuses. Conversely, the 0.45 ml/kg group showed improved embryonic survival and no significant treatment related adverse effects. Conclusion: The study identified a monotonous dose-response curve (MDRC), showing increasing adverse effects with higher CTI doses. The lowest observed adverse effect level (LOAEL) was 0.45 ml/ kg, and the no observed adverse effect level (NOAEL) was also determined at 0.45 ml/kg, suggesting limited safety margins for CTI use during pregnancy.
Medicinal plants have always been considered a healthy source of life for all people. In Mongolia, the use of various medicinal and food plants has a long history. In recent years, interest in plant-derived food additives has grown. This study was designed to determine essential oil chemical composition and evaluate antioxidant, cytotoxic activities of aerial parts serial fractions from Artemisia santolinifolia grown in Mongolia. The chemical composition of essential oil from A. santolinifolia was determined by GC-MS analysis. Among them 49 components -thujene (47.89%), sabinene ketone (11.78%), -thujene (3.98%), terpinen-4-оl (2.34%) were found to be the major ones. The ethanol crude extract of A.santolinifolia was suspended in water and consequently fractionated with n-hexane, chloroform, ethyl acetate and butyl alcohol. All the fractions were examined for their antioxidant and protective effect against tert-butylhydroperoxide-induced cell death by using DPPH and MTT assays, respectively. Ethyl acetate fraction showed the highest DPPH radical scavenging activity at a concentration of 50 µg/ml by 91.67% with the IC50 value of 12.03 µg/ml. MTT results showed that ethyl acetate, butanol and water fractions demonstrated significant protective effect against the oxidative stress in HepG2 cell line. These suggest that the fractions of A. santolinifolia could hold a good potential for use in the pharmaceutical industry.
Хүнсний бүтээгдэхүүнд нийлбэр афлатоксин болох Афлатоксин В1, В2, G1, G2 зэргийг тодорхойлох өндөр мэдрэмжит шингэний хроматографийн аргаар дээжийг иммуноаффинити багана ашиглан цэвэрлэн боловсруулсан. Энэ аргыг цагаан будаа, шар будаа болон лавлагаа дээж болох цагаан будаа, эрдэнэ шишийн гурилын дээжин дэх Нийлбэр афлатоксин тодорхойлж шинжилгээг баталгаажуулсан. Илрүүлэх хязгаар нь 0.14 мкг/кг байв. Нийлбэр афлатоксины судалгааг хүн амын түлхүү хэрэглэдэг импортын будааг санамсаргүй байдлаар цуглуулсан 6 дээжид шинжилгээ хийсэн. Үр дүн нь судалгааны сорьц болох 6 төрлийн импортын будаанд нийлбэр афлатоксин бохирдоогүй болно.
The previous study has shown that a naked mole rat that has a high tissue content of hyaluronan and its fragments is insensitive to pain. The previous study has also shown that hyaluronan modulates pain-regulated TRPV1 channel opening, reducing peripheral nociceptor activity and pain. The previous study has again shown that local injection of 35 kDa hyaluronan fragment HA35 is effective in treating inflammatory and neuropathic pain. This study employs a freshly made HA35 injection for treatment of pain associated with radiotherapy for treatment of colorectal and rectal cancer. A numerical rating scale from 0 to 10 was used to assess the pain after 1 hour, 3 hours, 24 hours, 48 hours and 72 hours of the injection. The results in this study indicate that HA35 of 100mg of abdominal deep fat layer injection effectively alleviates pain associated with radiotherapy, suggesting its important role in palliative care for patients with advanced colorectal and rectal cancer.
The global urgency for environmentally friendly technologies has steadily intensified, and as a result, the synthesis of silver nanoparticles with antibacterial properties derived from medicinal plants traditionally used to combat bacterial infections has garnered significant interest. Goals. This research endeavors to synthesize silver nanoparticles utilizing Jidanga and Banzdo plants, widely recognized in traditional medicine, while elucidating their physical, chemical attributes, and biological potential. Methods. The physicochemical characteristics of these silver nanoparticles, synthesized through phytosynthesis, were meticulously examined via various analytical techniques. Ultraviolet and visible light spectrophotometry (UV/Vis), Photon Cross Correlation Spectroscopy (PCCS), Atomic Force Microscope (AFM), Infrared Spectroscopy (FTIR), and X-ray Crystallography (XRD) were employed for comprehensive analysis. Additionally, their antitumor efficacy was assessed via MTT assay utilizing RAW264.7 cell cultures, while antibacterial properties were evaluated through agar diffusion tests against selected bacterial strains. Results. Silver nanoparticles exhibited distinctive UV/Vis absorption peaks at 407-426 nm, affirming their composition. PCCS measurements revealed nanoparticles with hydrodynamic diameters spanning from ~100 nm to ~450 nm, while AFM imaging showcased spherical nanoparticles ranging from ~35 nm to ~97 nm. Crystallography analysis identified both simple cubic and polycrystalline structures. FTIR analysis unveiled the presence of organic compounds adsorbed onto the nanoparticle surfaces, in addition to silver bonds. Notably, the aqueous and ethanolic extracts of Banzdo plants demonstrated dose-dependent inhibition of RAW264.7 cell growth via the MTT assay. Furthermore, the silver nanoparticles exhibited antibacterial activity against a range of test bacteria with inhibition zones spanning 1-4 mm. Conclusion, this study successfully synthesized silver nanoparticles utilizing Jidanga and Banzdo plants from traditional medicine, comprehensively characterizing their physicochemical attributes and demonstrating their biological activity. These findings hold promise for the future utilization of phytosynthetically derived silver nanoparticles. Keywords: Jidanga, Banzdo, silver nanoparticles, phytosynthesis Түлхүүр үг: Жиданга, банздо, мөнгөний нанопартикл, фитосинтез
A probiotics bacterium, such as lactic acid bacteria and bacillus sp are capable of hydrolyzing non-digestible saccharides, such as melibiose, raffinose, and stachyose, found in soy meal components. Strains S252 were hydrolyzed 26 types of saccharides and produced 11 types of enzymes, these were checked API 50CHB and API ZYM kit, specially β-galactosidase and α-glucosidase activity was high. Strains S254 were hydrolyzed 28 types of saccharides and produced 9 types of enzymes. The isolated strain S252 and S254 was identified as Weismannia coagulans by 16S rDNA analysis (99.81% and 99.72% of homology, respectively), and named as Weismannia coagulans S252 and Weismannia coagulans S254, previously known as Bacillus coagulans and before that as Lactobacillus sporogenes. Also revealed the biochemical properties of fermented soybean meal during 48 hours incubation and strains S252 and S254 was hydrolyzed anti nutritional compound, such as stachyose, raffinose and melibiose. After incubation 48h using strain S252, amount of stachyose, raffinose and melibiose was decreased from 17.23mg/g, 16.02mg/g, 23.07mg/g to 1.93mg/g, 5.96mg/g, 1.97mg/g, respectively. In the case of strain S252, amount of stachyose, raffinose and melibiose was decreased from 17.23mg/g, 16.02mg/g, 23.07mg/g to 1.20mg/g, 11.51mg/g, 4.64mg/g, respectively. At 24 hours fermentation, the viable cell count of strain S252 was highest 1.25x109. Viable cell count of strain S254 was increased rapidly from 1.89x106 to 2.23x109 than strain S252. These results suggest that fermented soybean meal by strain S252 and S254 has a hydrolyzing activity anti-nutritional soy meal component and could be utilized in feed manufacturing.
Green Synthesis of Silver Nanoparticles Using Jidanga and Banzdo Plant Extracts from Traditional Medicinal Sources A.Bayanmunkh1, D.Dejidmaa3, G.Oyuundelger1, O.Odgerel2, J.Boldbaatar1 1. Laboratory of food Analysis, Department of biology, School of Arts and Sciences, National University of Mongolia 2. Laboratory of Genetic Engineering, Department of chemical and biological engineering, School and applied science and engineering, National University of Mongolia 3. Laboratory of Nanomaterials, Center of Nanoscience and Nanotechnology, Department of Chemical and Biological Engineering, School of Applied Science and Engineering, National University of Mongolia, Ulaanbaatar 14200, Mongolia. Email:boldbaatar.j@seas.num.edu.mn Abstract The global imperative for environmentally friendly technologies has grown increasingly urgent. This research endeavors to synthesize silver nanoparticles utilizing Jidanga and Banzdo plants, widely recognized in traditional medicine, while elucidating their physical, chemical attributes, and biological potential. The physicochemical characteristics of these silver nanoparticles, synthesized through phytosynthesis, were meticulously examined via various analytical techniques. Ultraviolet and visible light spectrophotometry (UV/Vis), Photon Cross Correlation Spectroscopy (PCCS), Atomic Force Microscope (AFM), Infrared Spectroscopy (FTIR), and X-ray Crystallography (XRD) were employed for comprehensive analysis. Additionally, their antitumor efficacy was assessed via MTT assay utilizing RAW264.7 cell cultures, while antibacterial properties were evaluated through agar diffusion tests against selected bacterial strains. Silver nanoparticles exhibited distinctive UV/Vis absorption peaks at 407-426 nm, affirming their composition. PCCS measurements revealed nanoparticles with hydrodynamic diameters spanning from ~100 nm to ~450 nm, while AFM imaging showcased spherical nanoparticles ranging from ~35 nm to ~97 nm. Crystallography analysis identified both simple cubic and polycrystalline structures. FTIR analysis unveiled the presence of organic compounds adsorbed onto the nanoparticle surfaces, in addition to silver bonds. Notably, the aqueous and ethanolic extracts of Banzdo plants demonstrated dose-dependent inhibition of RAW264.7 cell growth via the MTT assay. Furthermore, the silver nanoparticles exhibited antibacterial activity against a range of test bacteria with inhibition zones spanning 1-4 mm. In conclusion, this study successfully synthesized silver nanoparticles utilizing Jidanga and Banzdo plants from traditional medicine, comprehensively characterizing their physicochemical attributes and demonstrating their biological activity. These findings hold promise for the future utilization of phytosynthetically derived silver nanoparticles. Keywords: Jidanga, Banzdo, silver nanoparticles, phytosynthesis
ЭМИЙН УРГАМАЛ АШИГЛАН ГАРГАН АВСАН МӨНГӨНИЙ НАНОПАРКТИКЛЫН БАКТЕРИЙН ЭСРЭГ ҮЙЛДЛИЙГ ТОГТООСОН ДҮН Ж.Болдбаатар1, Г.Оюундэлгэр1, Ж.Ирэхбаяр1, А.Баянмөнх2 1 Монгол улсын их сургууль, ХШУИС, Хими, биологийн инженерчлэлийн тэнхим 1 Монгол улсын их сургууль, ШУС, БУС, Биологийн тэнхими 1 Монгол улсын их сургууль, ШУС, БУС, Химийн тэнхим 2 Эм судлалын хүрээлэн, Монос групп Хураангуй: Мөнгөнийн нанопартикл нь бактерийн эсрэг өргөн эмчилгээний үйлдэлтэй бөгөөд орчин үед халдваргүйжүүлэх, ариутгах зорилгоор эмчилгээний бүтээгдэхүүн үйлдвэрлэхэд өргөнөөр ашиглаж байгаа хэдий ч гарган авах технологи нь өртөг өндөртэйд тооцогддог. Сүүлийн жилүүдэд ногоон технологи буюу эмийн ургамлыг ашиглан нанопартикл гарган авах технологи түгээмэл болж байгаа бөгөөд ургамлын бионэгдэлтэй нэгдсэн нэгдэл нь эмчилгээний үр дүн өндөр байх магадлалтай юм. Бидний судалгааны дүнд уламжлалт анагаах ухаанд бактерийн эсрэг үйлдэл бүхий Жиданга, Банздо ургамлыг ашиглан мөнгөний нитратаас ~142 – 221 нм хэмжээтэй, ургамлын бионэгдлийн 6 химийн холбоос агуулсан мөнгөнийн нанопартикл гарган авсан бөгөөд B.subtilis, P.aeruginosa E.faecalis, E. M.luteus бактерийн эсрэг үйлдэлтэй болохыг тогтоов. Түлхүүр үг: Мөнгөнийн нанопартикл, фотосинтез, эмийн ургамал, бактерийн эсрэг үйлдэл Оршил: Монгол улсын 1000 хүн ам тутамд өдөрт 64,41 нэгж тун антибиотик ноогдож байгаа нь антибиотикийн хэрэглээ өндөртөй орны тоонд орж байна. Антибиотик нь бактерийн гаралтай өвчлөлд үр дүнтэй боловч сүүлийн хэдэн арван жил түүний зохисгүй хэрэглээ нь эмчилгээний үр дүнг бууруулж байгаагаас гадна ихэнх өвчин үүсгэгч бактериуд антибиотикт тэсвэртэй болсон байна. Тухайлбал манай улсын 2019 оны антибиотикийн хэрэглээ ба нянгийн тэсвэржилтийн судалгааны тайланд улсын 4-р шатлалын нэг эмнэлэгт антибиотикийн хэрэглээ зохисгүй түвшинд байсан ба грамм эерэг коккийн хувьд ампициллинд 48%, гентамицинд 55%, эритромицинд 57%, ципрофлоксацинд 18%, цефазолинд 45%, левомицетинд 45%, нитрофурантоинд 40%, триметопримд 75% тэсвэржсэн байна. Грам сөрөг савханцар Pseudomnonas нь ампициллинд 100%, гентамицинд 73%, эритромицинд 100%, ципрофлоксацинд 27%, цефазолинд 91%, левомицетинд 73%, нитрофурантоинд 100%, триметопримд 100% тэсвэржсэн байжээ 1. Сүүлийн жилүүдэд антибиотикийг орлохуйц нэгдлийг хайх судалгаа болон уламжлалт хэрэглэж ирсэн мөнгөнийн ионыг өөрчлөх замаар шинэ эм бэлдмэлийн судалгаа эрчимжсэн 2,3,4. Мөнгөнийн давсыг фотосинтезын /зарим тохиолдолд ногоон технологи ч гэж нэрлэнэ/ аргаар нанохэмжээст оруулах арга ихээхэн түгээмэл болж байгаа бөгөөд үүнд эмийн ургамлыг өргөн ашиглаж ихээхэн сонирхол татахуйцаас гадна эмийн ургамалтай хосолсон мөнгөнийн нэгдлийг эмчилгээнд ашиглах боломжийг олгох бололцоог бий болгож байна. Энэхүү ажлын хүрээнд бид Монголын уламжлалт анагаах ухааны жоронд нян нядлах чадалтай гэж тэмдэглэгдсэн ургамлаас 2 зүйл ургамлыг сонгон авч ногоон фотосинтезэд ашиглан мөнгөнийн нано партикл гарган авч бактерийн эсрэг болон эсийн хорон чанарыг судлав.
Эрүүл мэндийн сайд С.Чинзориг хэлэхдээ “Манай улсад жилд 100-120 хүүхэд хорт хавдраар оношлогддог таагүй мэдээлэл байна. Тархины хорт хавдартай хүүхдүүдийн тал хувь нь, цусны хорт хавдартай хүүхдүүдийн 70 хувь нь анх оношлогдсоноос хойш тав буюу түүнээс дээш жил амьдарч байгаа нь дэлхийн дунджаас бага байгаа юм. Иймд хүүхдийн хорт хавдрын тусламж үйлчилгээний чанар хүртээмж тэр дундаа эмийн чанар, хүртээмжийг сайжруулахад ЭМЯ-наас анхаарч хүүхдийн хорт хавдрын тусламж үйлчилгээ, чанар хяналтыг сайжруулах төлөвлөгөөг хэрэгжүүлж, манай улсад зонхилон тохиолдож буй зургаан төрлийн хорт хавдрын эмчилгээ оношилгооны удирдамжийг олон улсын стандартад нийцүүлэн шинэчилсэн (Мөнхзул, Б. 2023). Энэ оношилгоог шинэчлэхдээ JAK2 V617F генийг маркер болгон үздэг байгаа. Гэтэл HLA-B27 гений мутаци нь миелодиспластик синдром (цусны хорт хавдрын ангилалд хамрагддаг), түгмэл миелома (Multiple myeloma) үүсгэдэг байна. Миелодиспластик синдромтой холбоотой олон аутоиммуний өвчин байдаг ч Jaejoon Lee, Hyungjin Kim нар 2008 онд миелодиспластик синдромтой 40 настай эрийг нуруу барьцалдах өвчтэй гэж оношилсноор дээрх хоёр өвчнийг тээгчийг анх удаа тэмдэглэсэн байна (Khehra, N. 2023). Liu, Ai-chun нар 2014 онд тухайн өгүүлэлдээ спондилоартрит хэмээн буруу онош тавигдан эмчлүүлж байсан түгмэл миеломатай өвчтөний тухай бичсэн байна. M.Razzaghof, S.Movassaghi нар 2016 онд түгмэл миелома хорт хавдар нуруу барьцалдах өвчинтэй ижил шинж тэмдгээр илэрдэг тухай өгүүлжээ (P value from Chi-Square Calculator). Тухайн нөхцөл байдлыг эмч нар урьдчилан тооцохгүй бол зөв онош гаргахад хүндрэлтэй байна. Иймд HLA-B27, JAK2 V617F гений аль алины мутацийг үзэх шаардлагатай байна. Миелодиспластик синдром, түгмэл миелома хэмээх цусны хорт хавдрыг барьцалдах спондилит эмгэгээс ялган оношлоход чухал үүргийг гүйцэтгэнэ. Улмаар зөв оношлогдсоноор эмчилгээ зөв хийгдэж эхэлнэ.
